Midodrine impurities and related standards

Midodrine is held here as a working collection of 20 reference materials across 9 CAS numbers. 4 of the entries are impurity-type materials of the parent, 1 are salt or counter-ion variants and 2 carry a deuterium label and 1 are nitrosamine analogues. 9 entries carry a verified structure drawing, a coverage of 45%; the rest are listed without a structure rather than with an unverified one. 9 of them sit in tier A or B, meaning the data behind the page is complete enough to be indexed and quoted directly, while 11 remain tier C and are kept for search coverage. Relative response factors are what decide whether a percentage on a chromatogram means anything. Impurities that lack a chromophore, or whose ultraviolet maximum sits away from the detection wavelength used for the parent, under-respond by a factor that has to be established with a solution of the standard itself rather than assumed. A certificate that names the synthetic route the standard was qualified against is more useful than one that only reports purity, since the same impurity can arise from two routes and only one of them will be present in a given product.

Sources: DailyMed (US NLM) - MIDODRINE HYDROCHLORIDE TABLET [TRUPHARMA, LLC].

9 reference standards related to Midodrine held in the RSSE catalogue — pharmacopoeial impurities, non-compendial impurities, metabolites and labelled analogues where available.

In this group: 4 fine chemicals · 3 impurity reference standards · 1 drug metabolite standard · 1 pharmaceutical intermediate. CAS numbers are listed for 9 of 9; 9 entries carry a structure drawing.

On this page

9 reference standards

All entries — structure, identifiers and pack sizes

Midodrine

CAS 42794-76-3C12H18N2O4

MW 254.28

IN STOCKRS-U094270
Midodrine Hydrochloride

CAS 43218-56-0C12H18N2O4.HCl

MW 290.75

IN STOCKRS-U094272
Midodrine USP Related Compound A

CAS 60407-53-6C10H15NO3.HCl

MW 233.69

IN STOCKRS-M234003
M-2 Metabolite of Desglymidodrine

CAS 54942-64-2C9H13NO3

MW 183.2

IN STOCKRS-M234002
2-Azido-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)acetamide

CAS 60681-97-2C12H16N4O4

MW 280.28

IN STOCKRS-I004095
2-Chloro-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)acetamide

CAS 60681-99-4C12H16ClNO4

MW 273.71

IN STOCKRS-P001991
3,5-Dimethoxy-4-ethylbenzoic acid

CAS 55703-68-9C11H14O4

MW 210.23

IN STOCKRS-U068232
Midodrine impurity 1

CAS not assignedC12H17N3O5

MW 283.12

IN STOCKRS-I001812
Midodrine Impurity 2

CAS 1797102-13-6C12H17BrN2O4

MW 333.18

IN STOCKRS-M234001

9 reference standards

Frequently asked

How many Midodrine-related reference standards do you hold?

9 standards are listed on this page as of the latest catalogue build. CAS numbers are published for 9 of them and 9 entries carry a structure drawing. The catalogue is extended as new lots are released.

Can you supply a Midodrine impurity that is not listed here?

Yes. Non-compendial impurities can be quoted from a structure — a CAS number is not required. Send the structure, a SMILES string or the parent drug substance with your enquiry and we will come back with availability.

What documentation is supplied with Midodrine impurities?

Every lot ships with its own certificate of analysis. The certificate records the catalogue number, the batch number, the tests performed, the specification applied and the result obtained for that lot. A safety data sheet is supplied with the shipment.

Do you publish prices or a lead time for Midodrine impurities?

No price list is published: quotations are prepared per enquiry, because availability and packing depend on the lot and the quantity you need. Send the catalogue number and the quantity and a technical contact will answer with availability and a quotation.

Cannot find the impurity you need? Non-compendial impurities can be quoted from a structure — a CAS number is not required. Write to sales@rssechem.com.