Alprazolam impurities and related standards
Alprazolam is held here as a working collection of 96 reference materials across 36 CAS numbers. 69 of the entries are impurity-type materials of the parent, 1 are salt or counter-ion variants and 5 carry a deuterium label and 1 are nitrosamine analogues. 33 entries carry a verified structure drawing, a coverage of 34%; the rest are listed without a structure rather than with an unverified one. 33 of them sit in tier A or B, meaning the data behind the page is complete enough to be indexed and quoted directly, while 63 remain tier C and are kept for search coverage. The practical difficulty with a series of this size is not obtaining any one impurity but demonstrating that the set is complete. A validation package normally needs the specified impurities plus the unspecified ones above the reporting threshold, and the second group is where a catalogue either holds the material or does not. A certificate that names the synthetic route the standard was qualified against is more useful than one that only reports purity, since the same impurity can arise from two routes and only one of them will be present in a given product.
Sources: DailyMed (US NLM) - ALPRAZOLAM TABLET [ACTAVIS PHARMA, INC.].
36 reference standards related to Alprazolam held in the RSSE catalogue — pharmacopoeial impurities, non-compendial impurities, metabolites and labelled analogues where available.
In this group: 17 impurity reference standards · 10 fine chemicals · 3 stable isotope labelled standards · 3 pharmaceutical intermediates. CAS numbers are listed for 36 of 36; 36 entries carry a structure drawing.
On this page
36 reference standards
All entries — structure, identifiers and pack sizes
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Alprazolam
IN STOCKRS-A230005 -
Alprazolam EP Impurity A
IN STOCKRS-A230020 -
Alprazolam EP Impurity B
IN STOCKRS-A230017 -
Alprazolam EP Impurity C
IN STOCKRS-A230014 -
Alprazolam EP Impurity H
BACK ORDERRS-A230011 -
Alprazolam EP Impurity F
CUSTOM SYNTHESISRS-A230016 -
(5-Chloro-2-iodophenyl)(phenyl)methanone
CUSTOM SYNTHESISRS-Z401KRF -
1-Hydroxy Alprazolam
IN STOCKRS-A230015 -
1-Hydroxy Alprazolam-d5
IN STOCKRS-A230002 -
1-Hydroxyalprazolam glucuronide
BACK ORDERRS-A230003 -
2-(2-Bromo-acetylamino)-5-chloro-benzophenone
IN STOCKRS-I012210 -
3-Amino-6-chloro-4-(4-pyridinyl)-2-quinolinone Hydrazone
IN STOCKRS-P018268 -
4-(2-Benzoyl-4-chlorophenyl)-5-methyl-4H-1,2,4-triazole-3-carboxaldehyde
IN STOCKRS-P003698 -
4-Acetoxy Alprazolam
IN STOCKRS-A230008 -
4-Hydroxy Alprazolam (Compd. with methanol)
IN STOCKRS-A230001 -
4-Hydroxyalprazolam
IN STOCKRS-A230006 -
5-Chloro-2-(3-chloromethyl-4H-1,2,4-triazol-4-yl)-benzophenone
IN STOCKRS-I002334 -
7-Chloro-1-methyl-5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-4-amine
IN STOCKRS-U063327 -
Alprazolam 5,6-Epoxide
IN STOCKRS-A230013 -
Alprazolam Aminomethyl Ketone Hydrochloride
IN STOCKRS-A230022 -
Alprazolam-d3
IN STOCKRS-A230009 -
Alprazolam-d5
IN STOCKRS-A230010 -
Alprazolam-D5 (1.0 mg/mL in Methanol)
IN STOCKRS-Z400R21 -
Cyclopropylflualprazolam
CUSTOM SYNTHESISRS-U045165 -
Methanone, (5-amino-2-chlorophenyl)phenyl-
BACK ORDERRS-U088816 -
N-(2-benzoyl-4-chlorophenyl)-2,2,2-trichloroacetamide
BACK ORDERRS-U057803 -
Thionordiazepam
IN STOCKRS-U046804 -
Alprazolam Impurity 12
CUSTOM SYNTHESISRS-A230007 -
Alprazolam Impurity 14
CUSTOM SYNTHESISRS-U006301 -
Alprazolam Impurity 17
CUSTOM SYNTHESISRS-A230019 -
Alprazolam Impurity 42
IN STOCKRS-A230021 -
Alprazolam Impurity 44
CUSTOM SYNTHESISRS-A230004 -
Alprazolam Impurity 45
IN STOCKRS-A230012 -
Alprazolam Impurity 46
IN STOCKRS-A230018 -
Alprazolam Impurity 47
IN STOCKRS-A230025
![Chemical structure of 7-Chloro-1-methyl-5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-4-amine](/structures/w4/UZCOFCPJYLEACT-UHFFFAOYSA-N.webp?v=9)
![Chemical structure of [2-[3-(Aminomethyl)-5-methyl-4H-1,2,4-triazol-4-yl]-5-chlorophenyl]phenylmethanone](/structures/w4/WWADXOXMCNJJKR-UHFFFAOYSA-N.webp?v=9)
36 reference standards
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